Functional bioassays: cytotoxicity in vitro (ISO 10993-5), skin irritation (ISO 10993-10 / OECD 439), skin sensitisation (OECD 442 d/e), ocular irritation and corrosion (OECD 460 / 492), cell effector assays with various cell lines (cytotoxicity, apoptosis, ADCC, CDC), proliferation and reporter gene assays as well as the implementation and performance of in-vitro potency assays.